Journal
JOURNAL OF LIPID RESEARCH
Volume 53, Issue 11, Pages 2256-2265Publisher
ELSEVIER
DOI: 10.1194/jlr.M025874
Keywords
long-chain fatty acid; eating behavior; obesity risk; health
Categories
Funding
- Burgundy Council
- Centre National Inter-professionnel de l'Economie Laitiere (CNIEL)
- Canadian Diabetes Association [OG-3-11-3270-DD]
- Canada Research Chair in Regulatory Peptides
- Banting and Best Diabetes Centre Novo Nordisk Chair in Incretin Biology
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Glucagon-like peptide-1 (GLP-1) signaling modulates sweet-taste sensitivity in the mouse. Because circumvallate papillae (CVPs) express both GLP-1 and its receptor, a local regulation has been suggested. However, whether dietary lipids are involved in this regulation, as shown in the gut, is unknown. By using a combination of biochemical, immunohistochemical, and behavioral approaches, the present data i) confirm the role of GLP-1 signaling in the attraction for sucrose, ii) demonstrate that minute quantities of long-chain FAs (LCFAs) reinforce the attraction for sucrose in a GLP-1 receptor-dependent manner, iii) suggest an involvement of the LCFA receptor GPR120 expressed in taste buds in this system, and iv) support the existence of a regulation by GLP-1 of the lipid sensing mediated by lingual CD36. Therefore, oro-sensory detection of LCFAs may affect sweet and fatty taste responsiveness by controlling the secretion of lingual GLP-1. This regulatory loop, probably triggered by the LCFA-GPR120 interaction, might contribute to the high palatability of foods rich both in fat and sugar.-Martin, C., P. Passilly-Degrace, M. Chevrot, D. Ancel, S. M. Sparks, D. J. Drucker, and P. Besnard. Lipid-mediated release of GLP-1 by mouse taste buds from circumvallate papillae: putative involvement of GPR120 and impact on taste sensitivity. J. Lipid Res. 2012. 53: 2256-2265.
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