Journal
JOURNAL OF LIPID RESEARCH
Volume 52, Issue 4, Pages 801-807Publisher
ELSEVIER
DOI: 10.1194/jlr.M012963
Keywords
anti-oxLDL antibodies; genetics; low density lipoprotein
Categories
Funding
- National Heart, Lung and Blood Institutes [R01-HL-54900, R01-HL112883, R01-HL115215, N01-HV-68161, N01-HV-68162, N01-HV-68163, N01-HV-68164]
- National Center for Research Resources [MO1-RR-00425]
- Gustavus and Louis Pfeiffer Research Foundation, Denville, NJ
- Ladies Hospital Aid Society of Western Pennsylvania, Pittsburgh, PA
- Women's Guild of Cedars-Sinai Medical Center
- Edythe L. Broad Women's Heart Research Endowment
- Cedars-Sinai Medical Center
- Cedars-Sinai Medical Center, Los Angeles, CA
Ask authors/readers for more resources
Atherosclerosis is the major cause of coronary artery disease (CAD), and oxidized LDL (oxLDL) is believed to play a key role in the initiation of the atherosclerotic process. Recent studies show that inflammation and autoimmune reactions are also relevant in atherosclerosis. In this study, we examined the association of antibodies against oxLDL (anti-oxLDL) with the severity of CAD in 558 Women's Ischemia Syndrome Evaluation (WISE) study samples (465 whites; 93 blacks) determined by coronary stenosis (<20%, 20%-49%, >50% stenosis). We also examined the relationship of anti-oxLDL with serum lipid levels and nine candidate genes including APOE, APOH, APOA5, LPL, LRP1, HL, CETP, PON1, and OLR1. IgM anti-oxLDL levels were significantly higher in the >20% stenosis group than in the boolean AND 20% stenosis group in whites (0.69 +/- 0.02 vs. 0.64 +/- 0.01, respectively; P = 0.02). IgM anti-oxLDL levels correlated significantly with total cholesterol (r(2) = 0.01; P = 0.03) and LDL cholesterol (r(2) = 0.017; P = 0.004) in whites. Multiple regression analysis revealed a suggestive association of LPL/S447X single-nucleotide polymorphism (SNP) with both IgG anti-oxLDL (P = 0.02) and IgM anti-oxLDL (P = 0.07), as well as between IgM anti-oxLDL and the OLR1/3'UTR SNP (P = 0.020).jlr Our data suggest that higher IgM anti-oxLDL levels may provide protection against coronary stenosis and that genetic variation in some candidate genes are determinants of anti-oxLDL levels.-Chen, Q., S. E. Reis, C. Kammerer, W. Craig, D. M. McNamara, R. Holubkov, B. L. Sharaf, G. Sopko, D. F. Pauly, C. N. B. Merz, and M. Ilyas Kamboh for the WISE study group. Association of anti-oxidized LDL and candidate genes with severity of coronary stenosis in the WISE study. J. Lipid Res. 2011. 52: 801-807.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available