Journal
JOURNAL OF LIPID RESEARCH
Volume 50, Issue -, Pages S120-S125Publisher
ELSEVIER
DOI: 10.1194/jlr.R800026-JLR200
Keywords
cholesterol; catabolism; liver; transporters; nuclear receptors
Categories
Funding
- National Institutes of Health [P01 HL-20948, PL1 DK-81182]
- Robert A. Welch Foundation [I-0971]
- Perot Family Fund
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There are two major pathways that mammalian cells use to supply themselves with cholesterol, one involving the synthesis of sterols from acetyl-CoA and the other the metabolism of cholesterol-rich lipoprotein particles via receptor-mediated endocytosis. There also are several pathways that mammalian cells use to break down cholesterol, and these disposal pathways are equal in physiological importance to the supply pathways. A major catabolic route involves conversion of cholesterol into conjugated bile salts, a transformation mediated by 16 or more liver enzymes.jlr This review highlights findings in cholesterol catabolism from the last five decades with special emphasis on advances in bile acid synthesis, transport, and regulation. Russell, D. W. Fifty years of advances in bile acid synthesis and metabolism. J. Lipid Res. 2009. S120-S125.
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