Journal
JOURNAL OF LIPID RESEARCH
Volume 50, Issue -, Pages S40-S45Publisher
ELSEVIER
DOI: 10.1194/jlr.R800062-JLR200
Keywords
arachidonic acid; leukotriene; inflammation
Categories
Funding
- Swedish Research Council [03X217]
- Karolinska Institutet
- European Union [LSHM-CT-2004-005033]
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5-Lipoxygenase (5-LO) catalyzes two steps in biosynthesis of leukotrienes (LTs), a group of lipid mediators of inflammation derived from arachidonic acid (AA). LT antagonists are used in treatment of asthma; more recently a potential role also in atherosclerosis has raised considerable interest. Furthermore, possible effects of 5-LO metabolites in relation to tumorigenesis have emerged.jlr Thus, an understanding of the biochemistry of this lipoxygenase has potential implications for treatment of various diseases.-Radmark, O., and B. Samuelsson. 5-Lipoxygenase: mechanisms of regulation. J. Lipid Res. 2009. S40-S45.
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