Related references
Note: Only part of the references are listed.Niemann-Pick C1-like 1 is required for an LXR agonist to raise plasma HDL cholesterol in mice
Weiqing Tang et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2008)
The cholesterol absorption inhibitor ezetimibe acts by blocking the sterol-induced internalization of NPC1L1
Liang Ge et al.
CELL METABOLISM (2008)
Madin-darby canine kidney II cells:: A pharmacologically validated system for NPC1L1-mediated cholesterol uptake
Adam B. Weinglass et al.
MOLECULAR PHARMACOLOGY (2008)
Liver X receptor β (LXRβ):: A link between β-sitosterol and amyotrophic lateral sclerosis-Parkinson's dementia
Hyun-Jin Kim et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Plant sterols cause macrothrombocytopenia in a mouse model of sitosterolemia
Janine K. Kruit et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Multiple plasma membrane receptors but not NPC1L1 mediate high-affinity, ezetimibe-sensitive cholesterol uptake into the intestinal brush border membrane
Martin Knoepfel et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2007)
Class B type I scavenger receptor is responsible for the high affinity cholesterol binding activity of intestinal brush border membrane vesicles
Eric D. Labonte et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2007)
NPC1L1 (Niemann-Pick Cl-like 1) mediates sterol-specific unidirectional transport of non-esterified cholesterol in McArdle-RH7777 hepatoma cells
J. Mark Brown et al.
BIOCHEMICAL JOURNAL (2007)
Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetirnibe
Ryan E. Temel et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Niemann-Pick C1-like 1 overexpression facilitates ezetimibe-sensitive cholesterol and β-sitosterol uptake in CaCo-2 cells
Yoshihide Yamanashi et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)
In vivo responsiveness to ezetimibe correlates with Niemann-Pick C1 like-1 (NPC1L1) binding affinity: Comparison of multiple species NPC1L1 orthologs
Brian E. Hawes et al.
MOLECULAR PHARMACOLOGY (2007)
Intestinal cholesterol absorption inhibitor ezetimibe added to cholestyramine for sitosterolemia and xanthomatosis
G Salen et al.
GASTROENTEROLOGY (2006)
Cholesterol-regulated translocation of NPC1L1 to the cell surface facilitates free cholesterol uptake
LQ Yu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Multiple rare variants in NPC1L1 associated with reduced sterol absorption and plasma low-density lipoprotein levels
JC Cohen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Sequence variation in NPC1L1 and association with improved LDL-cholesterol lowering in response to ezetimibe treatment
JS Simon et al.
GENOMICS (2005)
Intestinal cholesterol absorption is substantially reduced in mice deficient in both ABCA1 and ACAT2
RE Temel et al.
JOURNAL OF LIPID RESEARCH (2005)
Ezetimibe normalizes metabolic defects in mice lacking ABCG5 and ABCG8
LQ Yu et al.
JOURNAL OF LIPID RESEARCH (2005)
Caveolin-1 is not required for murine intestinal cholesterol transport
MA Valasek et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
The target of ezetimibe is Niemann-Pick Cl-Like 1 (NPC1L1)
M Garcia-Calvo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I
JM Timmins et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Inactivation of NPC1L1 causes multiple lipid transport defects and protects against diet-induced hypercholesterolemia
JP Davies et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Expression of ABCG5 and ABCG8 is required for regulation of biliary cholesterol secretion
LQ Yu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Compound heterozygosity for two non-synonymous polymorphisms in NPC1L1 in a non-responder to ezetimibe
J Wang et al.
CLINICAL GENETICS (2005)
Increased fecal neutral sterol loss upon liver X receptor activation is independent of biliary sterol secretion in mice
JK Kruit et al.
GASTROENTEROLOGY (2005)
Aminopeptidase N (CD13) is a molecular target of the cholesterol absorption inhibitor ezetimibe in the enterocyte brush border membrane
W Kramer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Ezetimibe effectively reduces plasma plant sterols in patients with sitosterolemia
G Salen et al.
CIRCULATION (2004)
Niemann-Pick C1 like 1 protein is critical for intestinal cholesterol absorption
SW Altmann et al.
SCIENCE (2004)
Selective sterol accumulation in ABCG5/ABCG8-deficient mice
LQ Yu et al.
JOURNAL OF LIPID RESEARCH (2004)
Niemann-Pick C1 like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis
HR Davis et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
ABCG5 and ABCG8 are obligate heterodimers for protein trafficking and biliary cholesterol excretion
GA Graf et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Compared with Acyl-CoA:cholesterol O-acyltransferase (ACAT) 1 and lecithin:cholesterol acyltransferase, ACAT2 displays the greatest capacity to differentiate cholesterol from sitosterol
RE Temel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Relation between hepatic expression of ATP-binding cassette transporters G5 and G8 and biliary cholesterol secretion in mice
A Kosters et al.
JOURNAL OF HEPATOLOGY (2003)
Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion
LQ Yu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol
LQ Yu et al.
JOURNAL OF CLINICAL INVESTIGATION (2002)
Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface
GA Graf et al.
JOURNAL OF CLINICAL INVESTIGATION (2002)
Targeted inactivation of sister of P-glycoprotein gene (spgp) in mice results in nonprogressive but persistent intrahepatic cholestasis
RX Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters
KE Berge et al.
SCIENCE (2000)
Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers
JJ Repa et al.
SCIENCE (2000)