Journal
JOURNAL OF LEUKOCYTE BIOLOGY
Volume 95, Issue 4, Pages 551-562Publisher
OXFORD UNIV PRESS
DOI: 10.1189/jlb.1113599
Keywords
antigen processing; cotranslational degradation; translation; ribosome; compartmentalization; nuclear translation
Categories
Funding
- Spanish Ministerio de Economia y Competitividad
- Fundacion Ramon Areces
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases, U.S. National Institutes of Health
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Review on the generation of antigenic peptides. MHC class I molecules display oligopeptides on the cell surface to enable T cell immunosurveillance of intracellular pathogens and tumors. Speed is of the essence in detecting viruses, which can complete a full replication cycle in just hours, whereas tumor detection is typically a finding-the-needle-in-the-haystack exercise. We review current evidence supporting a nonrandom, compartmentalized selection of peptidogenic substrates that focuses on rapidly degraded translation products as a main source of peptide precursors to optimize immunosurveillance of pathogens and tumors.
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