Journal
JOURNAL OF LEUKOCYTE BIOLOGY
Volume 96, Issue 1, Pages 39-48Publisher
FEDERATION AMER SOC EXP BIOL
DOI: 10.1189/jlb.1RU0114-010RR
Keywords
ROR gamma t; immune system; inflammation; tumor microenvironment
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Funding
- National Basic Research Program of China (973 Program) [2012CB9333004]
- Natural Science Foundation of China [81171983]
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Foxp3(+) T-regs have been known as a major regulator of immune homeostasis through their immunosuppressive function. Th17 lineage is a CD4(+) T cell subset that exerts its function by secreting proinflammatory cytokines and protecting host against microbial infections. The altered ratio between Foxp3(+) T-regs and Th17 cells plays an important role in the pathogenesis of immune-related diseases. Recent mice and human studies have demonstrated that T-regs can be reprogrammed into a novel population, IL-17(+)Foxp3(+) T cells, phenotypically and functionally resembling Th17 cells under the complicated cytokine stimulation. The identification of IL-17(+)Foxp3(+) T cells may provide a new understanding of therapy targeting T-regs and Th17 cells in autoimmune diseases and cancer. Here, we highlight significant data regarding the phenotype profile, origination, differentiation, and the pleiotropic functions of IL-17(+)Foxp3(+) T cells and the reciprocal relationships of these cells to T-regs and Th17 cells. Furthermore, the role of IL-17(+)Foxp3(+) T cells in tumorigenesis and clinical implications in cancer therapy are discussed in this review.
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