Journal
JOURNAL OF LEUKOCYTE BIOLOGY
Volume 94, Issue 4, Pages 595-601Publisher
WILEY
DOI: 10.1189/jlb.1112571
Keywords
PMN; lifespan; labeling; marginated pool; granulopoiesis; bone marrow
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Funding
- Dutch Lung Foundation [3.2.10.052]
- Netherlands Organization for Scientific Research (NWO) [917.96.350, 836.07.002]
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Neutrophils are the most abundant white blood cells and are indispensable for host defense. Recently, they have also been implicated in immune regulation and suppression. The latter functions seem hard to reconcile with the widely held view that neutrophils are very short-lived, with a circulatory half-life of < 7 h. To reopen the discussion on the average neutrophil half-life, we review and discuss experiments performed in the 1950s, 1960s, and 1970s, as well as recent in vivo labeling experiments. We reappraise the current knowledge on neutrophil half-lives, including their production in the bone marrow, their residency in the circulation and marginated pool, and their exit from the circulation.
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