4.5 Review

The not-so-neutral role of microRNAs in neutrophil biology

Journal

JOURNAL OF LEUKOCYTE BIOLOGY
Volume 94, Issue 4, Pages 575-583

Publisher

FEDERATION AMER SOC EXP BIOL
DOI: 10.1189/jlb.1012539

Keywords

Modulation of cellular function; miR-223; cathepsins; post-transcriptional control

Funding

  1. Australian National Health and Medical Research Council [1022144]
  2. Victorian Government's Operational Infrastructure Support Program

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The role of microRNAs (miRNAs) as fine-tuners of gene expression is now well established in most aspects of cellular biology. Critically, it is becoming apparent that characterization of miRNA regulation could further the understanding of elusive cellular processes. Here, I briefly review the current literature assessing the role of miRNAs in the modulation of neutrophil biology and discuss how the definition of such miRNA regulation could help in the better understanding of neutrophil function.

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