Journal
JOURNAL OF LEUKOCYTE BIOLOGY
Volume 89, Issue 5, Pages 669-673Publisher
FEDERATION AMER SOC EXP BIOL
DOI: 10.1189/jlb.0810446
Keywords
leukocytosis; neutrophil; priming; bone; repair
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Apart from their pivotal role in the host defense against pathogens, leukocytes are also essential for bone repair, as fracture healing is initiated and directed by a physiological inflammatory response. Leukocytes infiltrate the fracture hematoma and produce several growth and differentiation factors that regulate essential downstream processes of fracture healing. Systemic inflammation alters the numbers and properties of circulating leukocytes, and we hypothesize that these changes are maintained in tissue leukocytes and will lead to impairment of fracture healing after major trauma. The underlying mechanisms will be discussed in this review. J. Leukoc. Biol. 89: 669-673; 2011.
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