Journal
JOURNAL OF LEUKOCYTE BIOLOGY
Volume 88, Issue 3, Pages 475-481Publisher
WILEY
DOI: 10.1189/jlb.0310158
Keywords
macrophage; hormone; extrahepatic; somatomedin hypothesis
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Funding
- Medical Research Council [G9900991B] Funding Source: researchfish
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Growth hormone controls somatic growth in mammals by regulating the production of IGF-1, which is predominantly made by the liver. The development of cells within the MPS is controlled by the lineage-specific growth factor M-CSF (CSF-1). In this review, we summarize the role of CSF-1-dependent macrophages in somatic growth and organogenesis. We propose that macrophages are the major extrahepatic source of IGF-1 and that a surge of CSF-1 production contributes to the control of postnatal growth and organ maturation. Accordingly, CSF-1 may be considered a part of the GH/IGF-1 axis. J. Leukoc. Biol. 88: 475-481; 2010.
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