Journal
JOURNAL OF LEUKOCYTE BIOLOGY
Volume 85, Issue 3, Pages 335-343Publisher
WILEY
DOI: 10.1189/jlb.0808474
Keywords
adhesion deficiency; WHIM syndrome; Wiskott-Aldrich syndrome
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Funding
- Telethon [GGP07134]
- Fondazione Cariplo NOBEL
- EU grant FP7 HLH-Cure [201461]
- PRIN [2007ACZMMZ_005]
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Leukocyte recirculation through central and peripheral lymphoid organs and peripheral tissues is essential to maintain immune homeostasis. Some of the genetically determined, primary immunodeficiencies compromise leukocyte trafficking. Here, we review the mechanisms and consequences of impaired leukocyte trafficking in leukocyte adhesion-deficiency syndromes, Warts-Hypo-gamma-globulinemia-Infections-Myelokathexis syndrome and Wiskott-Aldrich syndrome. J. Leukoc. Biol. 85: 335-343; 2009.
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