Journal
JOURNAL OF LARYNGOLOGY AND OTOLOGY
Volume 127, Issue 3, Pages 239-245Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0022215113000017
Keywords
Ear, Inner; Perilymph; Administration, Transcutaneous; Pharmacokinetics; Gadolinium; Magnetic Resonance Imaging
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Funding
- National Natural Science Foundation of China [81070780]
- Capital Medical Development Scientific Research Foundation [20091015]
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Background: To investigate the feasibility of postauricular hypodermic injection for treating inner ear disorders, we compared perilymph pharmacokinetics for postauricular versus intravenous injection, using magnetic resonance imaging, in an animal model. Methods: Twelve albino guinea pigs were divided randomly into two groups and administered gadopentetate dimeglumine via either a postauricular or an intravenous bolus injection. A 7.0 Tesla magnetic resonance imaging system was used to assess the signal intensities of gadolinium-enhanced images of the cochlea, as a biomarker for changes in gadopentetate dimeglumine concentration in the perilymph. Pharmacokinetic parameters were calculated based on these signal intensity values. Results: Guinea pigs receiving postauricular injection showed longer times to peak signal intensity, longer elimination half-life, longer mean residence time and a greater area under the signal-time curve (from pre-injection to the last time point) (p < 0.05). Conclusion: Postauricular injection shows potential as an efficient drug delivery route for the treatment of inner ear disorders.
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