Journal
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
Volume 54, Issue 5, Pages 256-259Publisher
WILEY-BLACKWELL
DOI: 10.1002/jlcr.1862
Keywords
radiosynthesis; tritium-labeled; neonicotinoids; (NaBH4)-H-3
Funding
- National Basic Research Program of China (973 Program) [2010CB126104]
- Ministry of Agriculture of China [200803034]
- National High Technology Research and Development Program of China (863 Program) [2010AA10A204]
- National Science Foundation China [20872034]
- Science Foundation of Chinese University, Shanghai Foundation of Science and Technology [09391911800, 09XD1401300]
- Shanghai Leading Academic Discipline Project [B507. 111, B07023]
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Paichongding and Cycloxaprid are two novel neonicotinoids with good industrialization prospects for their high activity against imidacloprid-resistant pest. In this paper, the radiosynthesis of [H-3(2)]-Paichongding and [H-3(2)]-Cycloxaprid was achieved using a (NaBH4)-H-3 reduction. The title compounds were obtained with chemical purities of 98.7 and 98.4%, and radiochemical purities of 97.3 and 98.6%, respectively. The labeled compounds could be used as radiotracers for further study of metabolism and toxicology.
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