Journal
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
Volume 54, Issue 4, Pages 173-174Publisher
WILEY-BLACKWELL
DOI: 10.1002/jlcr.1837
Keywords
radioiodination; polymer; organotrifluoroborates; radiopharmaceuticals
Funding
- U.S. Department of Energy
- Robert H. Cole Foundation
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To simplify the purification of radiolabeled compounds, a novel strategy that combines the advantages of polymer chemistry and organotrifluoroborate chemistry was examined. It was discovered that the no-carrier-added radioiodination of readily prepared Dowex-supported organotrifluoroborates can be successfully achieved using a variety of oxidants, including a polymer-supported oxidant.
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