Journal
JOURNAL OF INVESTIGATIVE DERMATOLOGY
Volume 133, Issue 4, Pages 973-979Publisher
ELSEVIER SCIENCE INC
DOI: 10.1038/jid.2012.456
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Funding
- Damon Runyon Clinical Investigator Award
- NIH/NCI [P50 CA9368305]
- NIH/NIAID [R01 A1025082]
- University Medical Center Utrecht Internationalization Committee
- [R01 AR056720]
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Although CD4(+) T cells are known to contribute to the pathology of atopic dermatitis (AD) and psoriasis, the role of CD8(+) T cells in these diseases remains poorly characterized. The aim of this study was to characterize the cytokine production of T cells from AD and psoriasis skin. We found that CD4(+) T cells isolated from AD skin were largely Th2 (T helper type 2) biased, in agreement with prior reports. However, we also observed large numbers of CD8(+) T cells producing IL-13, IFN-gamma, and IL-22. We observed increased numbers of CD8(+) T cells isolated from AD skin, and immunohistochemistry studies confirmed the presence of CD8(+) T cells in the dermis and epidermis of AD skin lesions. Surprisingly, T-cell cytokine production was similar in the lesional and nonlesional skin of patients with AD. T cells from psoriatic lesional skin predominantly produced IFN-gamma, IL-17, and IL-22, in agreement with prior studies. However, in addition to Th17 cells, we observed high percentages of CD8(+) T cells that produced both IL-22 and IL-17 in psoriatic skin lesions. Our findings demonstrate that CD8(+) T cells are a significant and previously unappreciated source of inflammatory cytokine production in both AD and psoriasis. Journal of Investigative Dermatology (2013) 133, 973-979; doi:10.1038/jid.2012.456; published online 6 December 2012
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