Journal
JOURNAL OF INVESTIGATIVE DERMATOLOGY
Volume 133, Issue 11, Pages 2505-2508Publisher
ELSEVIER SCIENCE INC
DOI: 10.1038/jid.2013.271
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Funding
- NIA NIH HHS [P01AG036675, P01 AG036675] Funding Source: Medline
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In this issue, Takekoshi et al. investigated the role of CXCR4 in IL-23-induced keratinocyte hyperproliferation using an epidermal-specific knockout mouse model and found that CXCR4 limited keratinocyte proliferation. Some reports in the literature support this idea, whereas others contradict it; this disparity may be related to the differential roles of CXCR4 in various cell types or to a recently identified second receptor (CXCR7). Nevertheless, CXCR4 and its ligand SDF-1 have been implicated in skin wound healing, systemic lupus erythematosus, and basal cell carcinoma tumor angiogenesis. Further study is merited.
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