Journal
JOURNAL OF INVESTIGATIVE DERMATOLOGY
Volume 133, Issue 11, Pages 2503-2504Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/jid.2013.361
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As IL36RN mutations are a cause of generalized pustular psoriasis (GPP), three recent investigations attempted to correlate the IL36RN genotype with GPP clinical presentations. These studies found that IL36RN mutations account for only a fraction of GPP cases presenting with concomitant psoriasis vulgaris (PV; common or typical psoriasis). Pathogenic alleles were also found in control populations, indicating that environmental triggers and/or modifier genes may contribute to the disease.
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