Journal
JOURNAL OF INVESTIGATIVE DERMATOLOGY
Volume 133, Issue 4, Pages 907-912Publisher
ELSEVIER SCIENCE INC
DOI: 10.1038/jid.2012.387
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Funding
- European Society for Dermatological Research (ESDR)
- Hoffman LaRoche Advisory Boards
- GSK
- Pfizer
- Novartis
- Eli Lilly
- Galderma
- Canadian Institutes of Health Research
- British Columbia Ministry of Health
- Institute for Clinical Evaluative Sciences (ICES)
- Ontario Ministry of Health and Long-Term Care (MOHLTC)
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Limited evidence suggests that isotretinoin may be associated with inflammatory bowel disease (IBD). To explore this association, we conducted a retrospective population-based cohort study in British Columbia, Canada, among participants who were newly treated with isotretinoin or topical acne medications. The entire population of untreated provincial residents aged 12-29 years served as the reference group. During the 12-year study period, we identified 46,922 participants treated with isotretinoin, 184,824 treated with a topical acne medication, and 1,526,946 untreated individuals. Compared with untreated individuals, we observed no significant association between isotretinoin use and IBD (rate ratio (RR) 1.14; 95% confidence interval (CI) 0.92-1.41). As expected, we found no association with topical acne medications (RR 1.11; 95% CI 0.99-1.24). In prespecified secondary analyses, isotretinoin was associated with IBD among individuals aged 12-19 years (RR 1.39; 95% CI 1.03-1.87) and topical acne medications were associated with ulcerative colitis (RR 1.19; 95% CI 1.00-1.42). Our primary analyses found no association between isotretinoin and IBD. In prespecified secondary analyses, some evidence was found of associations with isotretinoin as well as topical acne medications, suggesting a possible association between IBD and acne itself. Additional research is needed to explore this possibility. Journal of Investigative Dermatology (2013) 133, 907-912; doi:10.1038/jid.2012.387; published online 25 October 2012
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