Journal
JOURNAL OF INVESTIGATIVE DERMATOLOGY
Volume 132, Issue 5, Pages 1321-1324Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/jid.2012.38
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Funding
- NIDDK NIH HHS [P30 DK019525] Funding Source: Medline
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The timing mechanism of the hair cycle remains poorly understood. However, it has become increasingly clear that the telogen-to-anagen transition is controlled jointly by at least the bone morphogenic protein (BMP), WNT, fibroblast growth factor (FGF), and transforming growth factor (TGF)-beta signaling pathways. New research shows that Fgf18 signaling in hair follicle stem cells synergizes BMP-mediated refractivity, whereas Tgf-beta 2 signaling counterbalances it. Loss of Fgf18 signaling markedly accelerates anagen initiation, whereas loss of Tgf-beta 2 signaling significantly delays it, supporting key roles for these pathways in hair cycle timekeeping.
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