Journal
JOURNAL OF INVESTIGATIVE DERMATOLOGY
Volume 131, Issue 4, Pages 969-976Publisher
ELSEVIER SCIENCE INC
DOI: 10.1038/jid.2010.404
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Funding
- Institut National de la Sante et de la Recherche Medicale, EuroTransBio [2006-004]
- Associazione Italiana per la Ricerca sul Cancro
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The natural cytotoxicity receptors NKp30, NKp44, and NKp46 were identified as activating receptors mainly expressed by natural killer (NK) lymphocytes. In this study we show that peripheral blood malignant CD4(+) T lymphocytes from patients with Sezary syndrome, an aggressive form of cutaneous T-cell lymphoma, express NKp46 at their cell surface. Although NKp46 does not behave as an independent functional receptor, its engagement provides a strong inhibiting signal on the malignant T lymphocyte CD3-induced proliferation. We show that this inhibition is correlated with a decreased phosphorylation of the CD3 zeta chain associated with NKp46 and/or the TCR/CD3 complexes. Our results reveal that in addition to KIR3DL2/CD158k expression, NKp46 could represent an additional marker on the circulating malignant T lymphocytes of Sezary patients, where it displays an as yet unreported function of inhibitory co-receptor able to interfere with the processes governing their CD3-dependent proliferation. Journal of Investigative Dermatology (2011) 131, 969-976; doi:10.1038/jid.2010.404; published online 30 December 2010
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