Journal
JOURNAL OF INVESTIGATIVE DERMATOLOGY
Volume 131, Issue 8, Pages 1600-1604Publisher
ELSEVIER SCIENCE INC
DOI: 10.1038/jid.2011.159
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Funding
- National Cancer Institute [CA076674, CA047159, CA093372]
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The utility of different models to identify cancer stem cells continues to be a subject of intense debate. Here, we summarize recent efforts to characterize intra-tumoral heterogeneity of melanoma and delineate key questions for future studies. Within a developing or already established tumor microenvironment, we propose that continuous tumor maintenance is assured by specific sub-populations whose phenotype is not static but instead is dynamically regulated. These small and temporarily distinct sub-populations likely have critical roles in tumor progression. They are important therapeutic targets, but only in the context of combination therapies, that also eliminate the bulk of the tumor.
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