Journal
JOURNAL OF INVESTIGATIVE DERMATOLOGY
Volume 130, Issue 10, Pages 2349-2351Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/jid.2010.215
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Funding
- NATIONAL CANCER INSTITUTE [P50CA093372, R21CA134391, R21CA116103] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR054593] Funding Source: NIH RePORTER
- NCI NIH HHS [R21 CA116103, R21CA116103, R21 CA116103-01A2, P50 CA093372, R21 CA134391, P50CA093372, 5R21CA134391] Funding Source: Medline
- NIAMS NIH HHS [R01 AR054593, R01AR054593, R01 AR054593-01A2] Funding Source: Medline
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Circulating tumor cells (CTCs) are cancer cells shed from either a primary tumor or its metastases that circulate in the peripheral blood. CTCs are potential seeds for metastases, and analyses of CTCs may allow earlier detection of metastasis-capable malignancy, monitoring for tumor recurrence, and accurate prognostication. Studies on CTCs have focused mainly on the detection of epithelial cancer cells. In this issue, De Giorgi et al. show that CTCs can be detected in melanoma patients using a filtration method, and that a higher percentage of patients with metastatic melanoma have detectable CTCs than do patients with primary melanoma.
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