Journal
JOURNAL OF INVERTEBRATE PATHOLOGY
Volume 103, Issue 1, Pages 79-81Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jip.2009.10.006
Keywords
Bombyx mori.; Densovirus; Nid-1; nsd-1; Resistance; Non-susceptibility; Non-structural protein 1 (NS1)
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Funding
- Ministry of Agriculture, Forestry and Fisheries of Japan
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In the silkworm Bombyx mori, densovirus type I (BmDNV-1) replicates only in the midgut and causes fatal disease. Resistance to BmDNV-1 is determined by two genes, nsd-1 and Nid-1, respectively. Neither of them has been identified yet. We investigated the viral transcript by RT-PCR in inoculated silkworms carrying different sets of nsd-1 and Nid-1 genotype. BmDNV-1 transcript was not detected in nsd-1-carrying strains irrespective of existence of Nid-1 but clearly detected in strains carrying Nid-1 without nsd-1. The result suggests that nsd-1 blocks early step of infection. On the other hand, Nid-1 does not block cell and nucleus entry and viral transcription in nuclei but blocks later step in the viral infection cycle. (C) 2009 Elsevier Inc. All rights reserved.
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