Journal
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
Volume 31, Issue 1, Pages 3-16Publisher
SPRINGER
DOI: 10.1007/s10840-010-9529-x
Keywords
Gene therapy; Cell therapy; Arrhythmias
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Funding
- USPHS-NHLBI [H1-28968, HL-67101, HL-094410]
- NYSTEM [CO24344]
- Netherlands Foundation for Cardiovascular Research (NFCVR)
- Dr. Saal van Zwanenberg foundation
- Interuniversity Cardiology Institute of the Netherlands (ICIN)
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The morbidity and mortality of cardiac arrhythmias are major international health concerns. Drug and device therapies have made inroads but alternative approaches are still being sought. For example, gene and cell therapies have been explored for treatment of brady- and tachyarrhythmias, and proof of concept has been obtained for both biological pacing in the setting of heart block and gene therapy for ventricular tachycardias. This paper reviews the state of the art developments with regard to gene and cell therapies for cardiac arrhythmias and discusses next steps.
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