Journal
OTOLOGY & NEUROTOLOGY
Volume 36, Issue 9, Pages 1532-1536Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MAO.0000000000000853
Keywords
Benign paroxysmal positional vertigo; Biomarkers; Otolin-1; Osteoporosis; Vitamin D
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Funding
- National Institutes of Health [M01RR006192/RR/NCRR]
- Division of Otolaryngology-Head and Neck Surgery, University of Connecticut School of Medicine
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Objective:To test the hypothesis that levels of a BPPV biomarker, otolin-1, correlate with those of osteoporosis markers, aminoterminal propeptide of protocollagen type I (P1NP), and aminoterminal telopeptides of collagen (NTX), thus further supporting a link between the two diseases.Study Design:Prospective pilot clinical trial (Level of Evidence: 2b).Patients:Postmenopausal women with BPPV.Interventions:Diagnostic.Main Outcome Measures:Serum levels of otolin-1, P1NP, NTX, vitamin D, and calcium were examined in relation to each other, age, and DEXA scan T-scores.Results:There was a strong, negative correlation between T-scores and otolin-1 levels. Although P1NP and NTX levels were strongly correlated, neither had statistical correlations with otolin-1.Conclusions:Despite a strong correlation between DEXA scan results and otolin-1 levels, there were no significant correlations between otolin-1 and P1NP or NTX. This suggests that the association between osteoporosis and BPPV is complex, but not likely to be causal. Although more work is needed to elucidate these relationships, this preliminary finding has important practical implications for BPPV in that proactive management of osteoporosis, per se, would not be expected to have benefits in management of BPPV.
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