Journal
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
Volume 42, Issue 6, Pages 1222-1231Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0300060514548291
Keywords
Mucociliary clearance; bronchoscopy; humidity; temperature; heated humidifier; mucus transport; general anaesthesia; mechanical ventilation
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Objective: To evaluate the effects of heated humidified ventilation on mucociliary function during general anaesthesia. Methods: Male patients (ASA physical status 1 or 2), scheduled for elective radical retropubic prostatectomy, were allocated to receive sevoflurane general anaesthesia with conventional or heated humidified ventilation. Bronchial mucus transport velocity was assessed via fibreoptic bronchoscope and methylene blue dye at 3h after induction of anaesthesia. Results: Median (SE) bronchial mucus transport velocity was significantly higher in the heated humidified group (n = 26) than the conventional ventilation group (n = 24) (1.7 [0.3] mm/min vs 0.9 [0.1] mm/min). Conclusion: Heated humidified ventilation effectively maintains mucociliary clearance of patients during sevoflurane general anaesthesia.
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