Journal
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
Volume 42, Issue 1, Pages 138-144Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0300060513501751
Keywords
Interleukin 17; knee; osteoarthritis; plasma; synovial fluid
Funding
- Natural Science Foundation of China [81201401, 30973539]
- Fundamental Research Funds for the Central Universities [303274010]
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Objective To determine interleukin (IL)-17 concentrations in serum and synovial fluid from patients with knee osteoarthritis, and evaluate their correlation with disease severity. Methods Serum and synovial fluid were collected from patients with primary knee osteoarthritis; age- and sex-matched healthy control subjects provided serum samples. This study was conducted retrospectively. IL-17 was quantified by enzyme-linked immunosorbent assay. Osteoarthritis severity and grade were assessed using the Lequesne index and Kellgren and Lawrence (KL) grading system, respectively. Results Serum IL-17 concentrations were significantly higher in patients (n=98) than in controls (n=50). In the patient group, the synovial fluid IL-17 concentration increased significantly with KL grade and was significantly positively correlated with Lequesne index (r=0.6232). Conclusions The synovial fluid IL-17 concentration could represent a useful biochemical marker to reflect knee osteoarthritis severity and progression.
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