Journal
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
Volume 40, Issue 3, Pages 1108-1113Publisher
FIELD HOUSE PUBLISHING LLP
DOI: 10.1177/147323001204000330
Keywords
PARKINSON'S DISEASE; SUBTHALAMIC NUCLEUS DEEP BRAIN STIMULATION; FREEZING OF GAIT; ACTIVITIES OF DAILY LIVING; MOTOR FUNCTION; NEUROPSYCHOLOGICAL FUNCTION; STEREOTACTIC NEUROSURGERY
Funding
- National Natural Science Foundation of China, Xi'an, China [81172095]
- Fourth Military Medical University, Xi'an, China [2009D07]
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OBJECTIVE: A prospective cohort study to evaluate the efficacy of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on freezing of gait (FOG) in patients with advanced Parkinson's disease. METHODS: Patients (n = 10) with advanced Parkinson's disease were surgically implanted with microelectrodes to facilitate STN-DBS. Evaluations of FOG, motor function, activities of daily living and neuropsychological function were carried out in on-medication and off-medication states (with and without levodopa treatment), before surgery and at 6 and 12 months postoperatively. RESULTS: STN-DBS was associated with significant improvement in FOG score and neuropsychological function at both 6 and 12 months postoperatively, compared with preoperatively. Significant postoperative improvements were also observed in motor function and activities of daily living. Daily levodopa dosage was significantly lower at both 6 and 12 months postoperatively. CONCLUSIONS: STN-DBS improved FOG in patients with advanced Parkinson's disease. The significant reduction in levodopa dosage and improvement in neuropsychological function may be the reason for the therapeutic effect seen with STN-DBS.
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