Overweight, Obesity and Thyroid Cancer Risk: a Meta-analysis of Cohort Studies

OBJECTIVE: This meta-analysis examined the relationship between excess body weight or body mass index (BMI) and risk of thyroid cancer. METHODS: PubMed (R), MEDLINE (R), EMBASE (TM) and Academic Search (TM) Premier databases were searched to identify cohort studies examining the effect of being overweight or obese on the risk of thyroid cancer. RESULTS: The inclusion criteria were met by seven cohort studies (total number of thyroid cancer cases, 5154). The pooled relative risk (RR) of thyroid cancer was 1.13 (95% confidence interval [CI] 1.04, 1.22) for overweight. Obesity was also linked with increased thyroid cancer risk in males and females, the strength of the association increasing with increasing BMI. The combined RR of thyroid cancer was 1.18 (95% CI 1.11, 1.25) for excess body weight (overweight and obesity combined). Being overweight was associated with a significant increase in thyroid cancer risk among non-Asians, but not among Asians. Overweight, obesity and excess body weight were all associated with papillary thyroid carcinoma risk. CONCLUSIONS: The association between overweight/obesity/excess body weight and thyroid cancer risk was confirmed.