Serum Amyloid A Low-density Lipoprotein Levels and Smoking Status in Obese Japanese Patients

Serum amyloid A low-density lipoprotein (SAA-LDL) is formed by an oxidative interaction and is considered to be a new marker related to oxidative modification of LDL. As the effect of smoking on oxidized LDL is of concern, this study investigated the association between SAA-LDL and smoking status. A total of 578 Japanese obese outpatients (mean +/- SD age 50.5 +/- 14.3 years) were studied. Smoking status was examined via a self-reported questionnaire. Cardiometabolic variables, including high-sensitivity C-reactive protein (hsCRP), were analysed in addition to SAA-LDL. There was an increasing trend in SAA-LDL levels from non- to ex- to current smokers, and significantly higher SAA-LDL levels were observed in current smokers versus nonsmokers (median SAA-LDL level 36 mu g/ml versus 28 mu g/ml, respectively). This significant difference was reduced after adjusting for multiple confounders, including lipid levels. Smoking may be associated with increased levels of SAA-LDL in an obese Japanese population, but further studies are needed.