Journal
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
Volume 36, Issue 5, Pages 867-874Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/147323000803600501
Keywords
CHRONIC FATIGUE SYNDROME; CENTRAL NERVOUS SYSTEM; NEUROIMAGING; HYPOTHALAMIC-PITUITARY-ADRENAL AXIS; CORTICOSTEROIDS; BRAIN-DERIVED NEUROTROPHIC FACTOR; SEROTONIN SYSTEM; CYTOKINES
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An increasing amount of neuroimaging evidence supports the hypothesis that chronic fatigue syndrome patients have structural or functional abnormalities within the brain. Moreover, some neurotrophic factors, neurotransmitters and cytokines have also been evaluated in order to elucidate the mechanism of abnormal neuropsychic findings in chronic fatigue syndrome. In this review, we suggest that the focal point of chronic fatigue syndrome research should be transferred to the central nervous system.
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