Journal
JOURNAL OF INTERNAL MEDICINE
Volume 267, Issue 1, Pages 54-70Publisher
WILEY
DOI: 10.1111/j.1365-2796.2009.02185.x
Keywords
cell sheet technology; clinical applications; regenerative medicine; scaffold-free; thermoresponsive polymer
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Cell sheet technology (CST) is based on the use of thermoresponsive polymers, poly(N-isopropylacrylamide) (PIPAAm). The surface of PIPAAms is formulated in such a way as to make its typical thickness < 100 nm. In this review, we first focus on how the methods of PIPAAm-grafted surface preparations and functionalization are important to be able to harvest a functional cell sheet, to be further transplanted. Then, we present aspects of tissue mimics and three-dimensional reconstruction of a tissue in vitro. Finally, we give an overview of clinical applications and clinically relevant animal experimentations of the technology, such as cardiomyopathy, visual acuity, periodonty, oesophageal ulcerations and type 1 diabetes.
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