Journal
JOURNAL OF INTERNAL MEDICINE
Volume 267, Issue 1, Pages 71-88Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1365-2796.2009.02184.x
Keywords
bioactive nanostructures; peptide amphiphiles; regenerative medicine; self-assembly
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Funding
- NIBIB NIH HHS [R01 EB003806] Funding Source: Medline
- NINDS NIH HHS [R01 NS020013, R01 NS020778] Funding Source: Medline
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB003806] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS020778, R01NS020013] Funding Source: NIH RePORTER
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Peptide nanostructures containing bioactive signals offer exciting novel therapies of broad potential impact in regenerative medicine. These nanostructures can be designed through self-assembly strategies and supramolecular chemistry, and have the potential to combine bioactivity for multiple targets with biocompatibility. It is also possible to multiplex their functions by using them to deliver proteins, nucleic acids, drugs and cells. In this review, we illustrate progress made in this new field by our group and others using peptide-based nanotechnology. Specifically, we highlight the use of self-assembling peptide amphiphiles towards applications in the regeneration of the central nervous system, vasculature and hard tissue along with the transplant of islets and the controlled release of nitric oxide to prevent neointimal hyperplasia. Also, we discuss other self-assembling oligopeptide technology and the progress made with these materials towards the development of potential therapies.
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