Journal
JOURNAL OF INTERNAL MEDICINE
Volume 265, Issue 1, Pages 78-96Publisher
WILEY
DOI: 10.1111/j.1365-2796.2008.02043.x
Keywords
acquired immunodeficiency syndrome; human immunodeficiency virus; pathogenesis
Categories
Funding
- Wellcome Trust [DQAD-P04191]
- Westminster Medical School Research Trust [PMS/MMS-07/0810124]
- Intramural research Program of the CCR
- NCI
- Intramural AIDS Targeted Antiviral Program
- National Institutes of Health [AI 056927, AI068524]
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Infection of humans by the human immunodeficiency virus (HIV) causes a progressive, multifactorial impairment of the immune system eventually leading to the acquired immunodeficiency syndrome (AIDS). No cure or vaccine exists yet against HIV infection. More worrisome is the fact that despite having identified HIV as the cause of the AIDS, we still do not understand what pathogenic mechanisms lead to the debacle of the immune system. In this review we consider the extent and the limits of our knowledge of HIV pathogenesis, and how this knowledge may be used to design preventive and therapeutic approaches.
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