Journal
JOURNAL OF INTERNAL MEDICINE
Volume 266, Issue 1, Pages 84-98Publisher
WILEY
DOI: 10.1111/j.1365-2796.2009.02107.x
Keywords
embryonic development; parafibromin; parathyroid carcinoma
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Funding
- Medical Research Council, United Kingdom
- MRC Clinical Research Training Fellow
- Medical Research Council [G0601423, G9825289] Funding Source: researchfish
- MRC [G0601423, G9825289] Funding Source: UKRI
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Parafibromin is a predominantly nuclear protein with a tumour suppressor role in the development of hereditary and nonhereditary parathyroid carcinomas, and the hyperparathyroidism-jaw tumour syndrome, which is associated with renal and uterine tumours. Parafibromin is a component of the highly conserved PAF1 complex, which regulates transcriptional events and histone modifications. The parafibromin/PAF1 complex regulates genes involved in cell growth and survival, and via these, parafibromin plays a pivotal role in embryonic development and survival of adults.
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