Journal
JOURNAL OF INTERNAL MEDICINE
Volume 265, Issue 1, Pages 58-66Publisher
WILEY
DOI: 10.1111/j.1365-2796.2008.02042.x
Keywords
cytokine; cytotoxic T cells; gut; T-reg
Categories
Funding
- National Institutes of Health [NIH/NIAID R01 AI-057020]
- California HIV/AIDS Research Program [CH05-D-606]
- Pendleton Charitable Trust.
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI057020] Funding Source: NIH RePORTER
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Mucosal surfaces of the body serve as the major portal of entry for human immunodeficiency virus (HIV). These tissues also house a majority of the body's lymphocytes, including the CD4(+) T cells that are the major cellular target for HIV infection. Mucosal surfaces are defended by innate and adaptive immune mechanisms, including secreted antibodies and CD8(+) cytotoxic T cells (CTL). CTL in mucosal lymphoid tissues may serve to limit viral replication, decreasing the host's viral burden as well as reducing the likelihood of sexual transmission to a naive host. This review summarizes recent literature on HIV-specific T-cell responses in mucosal tissues, with an emphasis on the gastrointestinal tract.
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