Journal
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
Volume 34, Issue 9, Pages 707-715Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/jir.2013.0099
Keywords
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Funding
- National Natural Sciences Foundation of China [81200376, 81270637, 81070447, 81000210]
- China Postdoctoral Science Foundation [2012M510141]
- Foundation of Jiangsu Province Six Talents Peak [2012-WSN-082]
- Natural Science Foundation of Guangdong Province [s2011040003741]
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Graft-versus-host disease (GVHD) as a major complication after allogeneic hematopoietic stem cell transplantation is not well prevented now. We have observed that interleukin-22 (IL-22) produced by Th22, Th1, and Th17 cells participated in GVHD development in our previous study. However, the role of IL-22 in GVHD is still ambiguous. The aim of this study was to illuminate the pathological or protective function and the potential mechanism of IL-22 in the GVHD process. In the present study, we found that compared with mice co-transferred with bone marrow and spleen cells (BS mice) without IL-22 administration, more serious tissue damage and higher GVHD clinical score were observed in BS + IL-22 mice. IL-22 administration was a benefit to early recovery of thymus after irradiation-induced injury. Administration of IL-22 could promote Th1 and Tc1 cell expansion in mesenteric lymph nodes but reduce CD4(+) CD25(+) Foxp3(+) regulatory T (Treg) cell number. Levels of systemic inflammatory cytokines (IFN-gamma and TNF-alpha) were upregulated, while the level of immunosuppressive cytokine IL-10 was downregulated in recipients with IL-22 injection. In conclusion, IL-22, which exacerbates both local immune responses and systemic inflammation of recipients, plays a pathogenic role in the GVHD process. The potential mechanism of IL-22 in GVHD may attribute to increased alloreactive effector Th1 and Tc1 cells and decreased inhibitory Treg cell.
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