Journal
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
Volume 32, Issue 8, Pages 350-361Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/jir.2012.0014
Keywords
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Funding
- Australian NHMRC [1006590, 1022144]
- Monash University FMNHS Strategic Grant
- Victorian Government
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Recent advances in our understanding of foreign nucleic acid sensing indicate an important role for the human Toll-like receptor (TLR) 8 in the initiation of immune responses to certain pathogens. However, TLR8, far too often grouped together with TLR7 for its common ability to detect RNA, has a function on its own in the initiation of specific proinflammatory responses to viruses and bacteria. Here, we present an overview of what is currently known of human TLR8 biology, from genetic regulation to its function in innate immunity, and discuss how TLR8 could present novel therapeutic opportunities in viral and cancer diseases.
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