Journal
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
Volume 32, Issue 3, Pages 115-120Publisher
MARY ANN LIEBERT INC
DOI: 10.1089/jir.2011.0003
Keywords
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Funding
- Ministry of Health, China
- National Natural Science Foundation of China [30872815, 81170817]
- Science and Technology Commission of Shanghai Municipality [10XD1401100]
- Fudan University
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Natural killer (NK) cells are important in the ocular surface innate response against viral and bacterial infection. Major-histocompatibility-complex class I-related chain A (MICA) antigens are ligands of natural killer group 2D, an activating or coactivating receptor expressed on NK cells. Recent studies demonstrated that interferon-gamma (IFN-gamma) could modulate MICA expression in tumor cells. However, little is known about MICA expression and regulation in human corneal epithelium. Our study assessed whether the proinflammatory cytokine, IFN-gamma, affects MICA expression in human corneal epithelium. We identified low levels of surface MICA expression in corneal epithelium using flow cytometry. IFN-gamma promoted surface MICA expression in corneal epithelium and increased soluble MICA levels in a dose-dependent manner. IFN-gamma also enhanced NK cell-mediated cytotoxicity against the corneal epithelium. Anti-MICA antibodies could further block this process. In summary, we describe a novel IFN-gamma function in the regulation of the innate response in ocular surfaces.
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