Journal
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
Volume 31, Issue 10, Pages 769-779Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/jir.2011.0029
Keywords
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Funding
- National Institutes of Health [R01 AI49954, R01 AI068787, R01 AI085567]
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Systemic lupus erythematosus (SLE) is an autoimmune disease associated with chronic immune activation and tissue damage. Organ damage in SLE results from the deposition of immune complexes and the infiltration of activated T cells into susceptible organs. Cytokines are intimately involved in every step of the SLE pathogenesis. Defective immune regulation and uncontrolled lymphocyte activation, as well as increased antigen presenting cell maturation are all influenced by cytokines. Moreover, expansion of local immune responses as well as tissue infiltration by pathogenic cells is instigated by cytokines. In this review, we describe the main cytokine abnormalities reported in SLE and discuss the mechanisms that drive their aberrant production as well as the pathogenic pathways that their presence promotes.
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