Journal
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
Volume 30, Issue 9, Pages 643-652Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/jir.2010.0049
Keywords
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Funding
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL097564, R01HL057243] Funding Source: NIH RePORTER
- NHLBI NIH HHS [R01 HL097564, R01 HL057243] Funding Source: Medline
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Influenza is a common respiratory pathogen causing both seasonal and pandemic disease. Influenza infection predisposes the host to secondary bacterial infection of the respiratory tract, which is a major cause of both morbidity and mortality in flu-related disease. In this review, we will discuss innate and adaptive antiviral responses during influenza infection, and review how these responses modulate protective immunity against secondary bacterial pathogens of the lung. Specific emphasis will be placed on implications of bacterial superinfection and mechanisms involved.
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