Journal
JOURNAL OF INSTRUMENTATION
Volume 6, Issue -, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/1748-0221/6/01/C01044
Keywords
Pixelated detectors and associated VLSI electronics; Instrumentation and methods for time-of-flight (TOF) spectroscopy; Mass spectrometers
Categories
Funding
- U.K. Royal Society
- EPSRC [EP/G00224X/1]
- EU [FP7 ITN ICONIC]
- ERC [200733]
- ISIS Innovation Ltd
- Engineering and Physical Sciences Research Council [EP/G00224X/1] Funding Source: researchfish
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The application of fast detectors to microscope mode spatial imaging mass spectrometry, in which the two-dimensional distributions of particular ion masses over a sample are projected onto a two-dimensional detector, allows the imaging of all mass peaks desorbed from a sample on each time-of-flight cycle. Detecting all fragments per duty cycle means that fewer ionisation and acquisition cycles are required for a full set of data, leading to a reduction in overall detection time, amount of sample required, and sample degradation. Results from a proof-of-concept experiment, in which a fast frame transfer charge-coupled device camera (CCD) with 10 ns time resolution was coupled to a modified velocity-mapped imaging apparatus, are presented.
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