Journal
OSTEOARTHRITIS AND CARTILAGE
Volume 23, Issue 9, Pages 1506-1512Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.joca.2015.04.022
Keywords
Biomarkers; Collagen; C2C; Knee injury; Synovial fluid
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Funding
- Swedish Research Council
- Crafoord Foundation
- Faculty of Medicine Lund University
- Thelma Zoegas fund
- King Gustaf V 80-year Birthday Fund
- Kock Foundation
- Swedish Rheumatism Association
- Alfred Osterlunds Foundation
- Swedish National Centre for Research in Sports
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Purpose: Investigate in a cross-sectional study time-dependent changes of synovial fluid type II collagen epitope C2C concentrations after knee injury and correlate to other joint injury biomarkers. Methods: Synovial fluid samples were aspirated between 0 days and 7 years after injury (n = 235). Serum was collected from 71 of the knee injured patients. Synovial fluid from 8 knee-healthy subjects was used as reference. C2C was quantified by immunoassay and structural injury was determined from magnetic resonance images (MRI) of the injured knee acquired 1-38 days after injury (n = 98). Additional joint injury biomarker results were from earlier investigations of the same samples. Results: Synovial fluid C2C concentrations were higher in injured knees than in knees of reference subjects from 1 day up to 7 years after injury. C2C concentrations in synovial fluid and serum were correlated (r = 0.403, P < 0.001). In synovial fluid from subjects early after injury (0-33 days), C2C concentrations were correlated with cross-linked C-telopeptide of type II collagen (r = 0.444, P = 0.003), ARGS-aggrecan (r = 0.337, P < 0.001), osteocalcin (r = 0.345, P < 0.001), osteopontin (r = 0.371, P < 0.001) and IL-8 (r = -0.385, P < 0.001), but not with structural joint injury as visualized on MRI. Conclusion: The increased levels of synovial fluid C2C after injury, together with the associations seen with several other injury-related biomarkers, suggest that an acute knee injury is associated with an immediate and sustained local degradation of type II collagen. (C) 2015 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
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