Journal
JOURNAL OF INSECT PHYSIOLOGY
Volume 54, Issue 2, Pages 367-377Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jinsphys.2007.10.007
Keywords
diptera; adipokinetic hormone; neuropeptide; metabolism; flight
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Funding
- NIAID NIH HHS [R01 AI033108, R01 AI033108-08, AI 33108] Funding Source: Medline
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The role of adipokinetic hormones (AKHs) in the regulation of carbohydrate and lipid metabolism and flight performance was evaluated for females of the African malaria mosquito, Anopheles gambiae. Injection of various dosages of synthetic Anoga-AKH-I increased carbohydrate levels in the haemolymph and reduced glycogen reserves in sugar-fed females but did not affect lipid levels. Anoga-AKH-I enhanced the flight performance of both intact and decapitated sugar-fed females, during a 4 It flight period. AnogaAKH-II had no effect on carbohydrate or lipid levels or flight performance, thus its function remains unknown. Targeted RNA-interference lowered Anoga-AKH receptor expression in sugar-fed females, consequently injections of Anoga-AKH-I failed to mobilize glycogen reserves. Taken together, these results show that a primary role for the neurohormone, Anoga-AKH-I, is to elevate trehalose levels in the haemolymph of female mosquitoes. (c) 2007 Elsevier Ltd. All rights reserved.
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