Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 135, Issue -, Pages 54-57Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2014.03.001
Keywords
Water-soluble Au(I); N-heterocyclic carbene; Antibacterial
Funding
- CONICET [PIP 11220110100828]
- CIC [243/13]
- ANPCyT (Agencia Nacional de Promocion Cientifica y Tecnologica) [PICT 2012-1449]
- Universidad Nacional del Sur, Bahia Blanca, Argentina [24/Q038]
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The antibacterial properties of water-soluble gold(I) complexes [1-methyl-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C1), [1-mesityl-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C2), [1-(2,6-diisopropyl-phenyl)-3-(3-sulfonatopropyl)imidazol-2-ylidene]gold(I) chloride (C3) and [1,3-bis(2,6-diisopropyl-4-sodiumsulfonatophenyl)imidazol-2-ylidene]gold(I) chloride (C4) and the respective ligands were assessed by agar diffusion and broth macrodilution methods against Gram-positives Staphylococcus aureus, Enterococcus faecalis and Micrococcus luteus and the Gram-negative bacteria Yersinia ruckeri, Pseudomonas aeruginosa and Escherichia coll. Viability after treatments was determined by direct plate count. The bactericidal activity displayed by C1 and C3 was comparable to that of AgNO3. (C) 2014 Elsevier Inc. All rights reserved.
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