Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 127, Issue -, Pages 1-6Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2013.05.018
Keywords
Charged metalloporphyrin; Left-handed Z-DNA; hexamminecobalt(III) chloride; Spermine; Induced circular dichroism; DNA binding
Funding
- University of Wyoming
- University of Catania
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We report the chiroptical signature and binding interactions of cationic (meso-tetrakis(4-N-methylptridyl) porphyrin, 2HT4) and anionic (meso-tetrakis(4-sulfonatophenyl)porphyrin, 2HTPPS) porphyrins and their zinc(II) and nickel(II) derivatives (ZnT4, ZnTPPS, NiT4, and NiTPPS) with right-handed B-form and two forms of left-handed Z-form of alternating guanine-cytosine polydeoxynucleotide poly(dG-dC)(2). NiTPPS is able to spectroscopically discriminate between spermine-induced Z-DNA and Co(III)-induced Z-DNA via new induced circular dichroism signal in the visible region of the electromagnetic spectrum. (c) 2013 Elsevier Inc. All rights reserved.
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