Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 120, Issue -, Pages 39-43Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2012.12.002
Keywords
Diclofenac; Copper(II); Non-steroidal anti-inflammatory drug; Biological activity; Tumoral cell lines
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A copper(II) complex with the non-steroidal anti-inflammatory drug (NSAID) diclofenac has been for the first time synthesized and characterized without any co-organic ligand. Its biological activity against four human cell lines underlined a higher activity of the monomeric complex than the parent molecule in the case of tumoral cell lines. A ternary Cu-diclofenac-albumin complex was suspected to be the reactive species in biological medium. (C) 2013 Elsevier Inc. All rights reserved.
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