Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 129, Issue -, Pages 162-171Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2013.07.023
Keywords
Heme protein; Non-native state; Conformer; Catalysis; Sensor
Funding
- National Science Foundation of China [21101091, 90913022]
- Major State Basic Research Program of China [2010CB912301, 2009CB825505]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
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Heme proteins perform various biological functions ranging from electron transfer, oxygen binding and transport, catalysis, to signaling. Although adopting proper native states is very important for these functions, progresses in representative heme proteins, including cytochrome c (cyt c), cytochrome b(5) (cyt b(5)), myoglobin (Mb), neuroglobin (Ngb), cytochrome P450 (CYP) and heme-based sensor proteins such as CO sensor CooA, showed that various native functions, or new functions evolved, are also closely associated with non-native states. The structure and function relationship of heme proteins in non-native states is thus as important as that in native states for elucidating the precise roles of heme proteins in biological systems. (C) 2013 Elsevier Inc. All rights reserved.
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