Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 111, Issue -, Pages 33-39Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2012.02.022
Keywords
Ruthenium(III)pyrazole complexes; Crystal structure cyclic voltammetry; in vitro cytotoxicity
Funding
- Louisiana Board of Regents [LEQSF(2009-12)-RD-B-08]
- American Heart Association
- Texas Advanced Research Program
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A series of new water soluble Ru(III) pyrazole complexes mer-[RuCl3(DMSO-S)(pyz)(2)] 1, mer-[RuCl3(DMSO-S) (DMSO-O)(pyz)) 2, mer-[RuCl3(bpy)(dmpyz)] 3, and mer-[RuCl3(DMSO-S)(dmpyz)21 4 (pyz = pyrazole; dmpyz = 3,5-dimethylpyrazole, bpy = 2,2'-bipyridine) have been synthesized and characterized by use of a combination of spectroscopy (IR and UV-visible). X-ray diffraction, and cyclic voltammetry. The molecular X-ray structure of all reported compounds (1-4) revealed distorted octahedral coordination around ruthenium. The cytotoxicity assay on human breast cancer cells (MCF7) demonstrated that compounds 1 and 4 affect cell viability, whereas compounds 2 and 3 do not show appreciable activity. The IC50 values for 1 and 4 lie within the range of 71-32 mu M in MCF7 cells. (C) 2012 Elsevier Inc. All rights reserved.
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